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Daniel J. Buysse, M.D.

UPMC Professor of Sleep Medicine
Professor of Psychiatry and Clinical and Translational Science
University of Pittsburgh School of Medicine
3811 O’Hara St.
Pittsburgh, PA 15213
E: buyssedj@upmc.edu
T: (412) 246-6413
F: (412) 246-5300

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Education:

  • BA, University of Michigan (Ann Arbor, MI), 1981
  • MD, University of Michigan (Ann Arbor, MI), 1983
  • Postdoctoral Fellowship, University of Pittsburgh (Pittsburgh, PA), 1987-1989

Current Trainees:

  • Accepting Trainees: Yes

Research Interests:

Dr. Buysse has over 25 years of experience in sleep medicine research. His main areas of focus include sleep assessment and patient-reported outcomes; evaluation and treatment of insomnia; and sleep in aging. He has also investigated sleep in mood disorders, and the interaction between sleep and circadian physiology. This research uses a variety of techniques such as self-report, actigraphy, home and laboratory-based polysomnography, laboratory-based circadian assessments, and functional imaging studies. Dr. Buysse has also conducted clinical trials of behavioral treatment for insomnia.

Dr. Buysse has a long-standing record of teaching and mentoring. He has mentored (or is currently mentoring) 21 post-doctoral fellows, 11 of these as primary research mentor. He has also mentored 12 undergraduate or medical students on research electives. Nine of Dr. Buysse’s previous post-docs have received K awards, eight have obtained NIH R-series funding, and four are still in training. Dr. Buysse is Program Director of an NHLBI-funded T32 program, “Translational Research Training in Sleep Medicine” (HL082610-08), and on the training faculty of two other T32 programs and the institutional KL2 program through the Clinical and Translational Science Institute. Of 8 alumni of the sleep medicine T32, 5 have received K awards. Dr. Buysse is the prior recipient of a K24 award.

Dr. Buysse has served in national and local leadership positions. He is Past President of the American Academy of Sleep Medicine, a former member of the Board of Directors of the Society of Behavioral Sleep Medicine, and Chair of the Sleep Research Network. He has served as Chair of the Biobehavioral Mechanisms of Stress and Health (MESH) study section at NIH, and has served on several NIH panels, including the Program Committee for the NIH State-of-the-Science Conference on the Manifestations and Management of Chronic Insomnia in Adults. Dr. Buysse is Deputy Editor of the journal SLEEP, and has served as Deputy Editor of Journal of Clinical Sleep Medicine, and Associate Editor of Behavioral Sleep Medicine. At the University of Pittsburgh, he served as Director of the Neuroscience Clinical and Translational Research Center, a component of our GCRC then CTSI, for nearly 20 years. He is Co-Chair of the Department of Psychiatry Research Review Committee, and Chair of the K Award Review Program.

Current Research Funding:

  • UH2/UH3 HL125103 (Role: PI): Pragmatic Trial of Behavioral Interventions for Insomnia in Hypertensive Patients, 2014-2019
  • T32 HL082610 (Role: PI): Translational Research Training in Sleep Medicine, 2007-2022.
  • R01 AG047139 (Role: MPI): Sleep Circadian Rhythms, and Cardiometabolic Risk in Retired Shift Workers, 2015-2020.
  • R01 GM113243 (Role: Co-I): Collaborative Research: A Statistical Framework for the Spectral Analysis of Nocturnal Electrophysiological Time Series, 2018-2021.
  • R01 MH105513 (Role: Co-I): A Transdiagnostic Sleep and Circadian Treatment to Improve Community SMI Outcomes, 2014-2018.
  • R01 HL122460 (Role: Co-I): Neighborhood Change: Impact on Sleep and Obesity-Related Health Disparities, 2015-2018.
  • (Matthews) (Role: Co-I): Self-management via Health Kiosk by Community-Residing Older Adults, 2014-2019.
  • R01 AG047139 (Role: Co-I): Sleep, Circadian Rhythms, and Cardiometabolic Risk in Retired Shift Workers, 2015-2020.
  • U01 HL 128954 (Role: Co-I): Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC), 2015-2020.
  • R01 AG056331 (Role: Co-I): Sleep Health Profiles and Mortality Risk in Older Adults: A Multi-Cohort Application of Novel Statistical Methods, 2017-2020.
  • UL1 TGR001857 (Role: Co-I): University of Pittsburgh Clinical and Translational Science Institute: Hub Research Capacity Component (PCI) , 2016-2021.
  • R01 HL131587 (Role: Co-I): Improving Asthma Control Using Internet-based Cognitive-Behavioral Treatment for Insomnia, 2017-2021.
  • R01 AA025626 (Role: Co-I): Proximal Prospective Associations between Circadian Alignment, Reward Function and Alcohol use in Adolescents, 2017-2022.
  • (Patterson) (Role: Co-I): Real-Time Intervention to Reduce Fatigue Among Emergency Service Workers, 2018-2022.
  • R01 MH118312 (Role: Co-I): Longitundinal Study of Sleep Duration, Reward and Cognitive Control Curcuits, and vulnerability for Depressed and Suicidal Ideation During Adolescence, 2018-2023.

Selected Publications:

  1. Levenson JC, Kay DB, Buysse DJ. The pathophysiology of insomnia. Chest 147(4): 1179-1192, 2015.  PMCID: PMC4388122
  2. Kay DB, Buysse DJ, Germain A, Hall MH, Monk TH. Subjective-objective sleep discrepancy among older adults: Associations with insomnia diagnosis and insomnia treatment. Journal of Sleep Research 24(1):32-39, 2015. PMCID: PMC474029
  3. Buysse DJ. Sleep health: Can we define it? Does it matter? Sleep, 37(1):9-17, 2014. PMCID: PMC3902880
  4. Buysse DJ. Insomnia. JAMA-Journal of the American Medical Association, 309(7):706-716, 2013. PMCID: PMC3632369
  5. Yu L, Buysse DJ, Germain A, Moul DE, Stover A, Dodds NE, Johnston KL, Pilkonis PA. Development of short forms from PROMISTM Sleep Disturbance and Sleep-Related Impairment Item Banks. Behavioral Medicine, 10(1): 6-24, 2012. PMCID: PMC3261577
  6. Buysse DJ, Germain A, Hall M, Monk TH, Nofzinger EA. A neurobiological model of insomnia. Drug Discovery Today: Disease Models, 8(4): 129-137, 2011. PMCID: PMC3212043.
  7. Buysse DJ, Germain A, Moul DE, Franzen PL, Brar LK, Fletcher ME, Begley A, Houck PR, Mazumdar S, Reynolds CF, Monk TH. Efficacy of brief behavioral treatment for chronic insomnia in older adults. Archives of Internal Medicine, 171(10):887-895, 2011. PMCID: PMC3101289
  8. Buysse DJ, Yu L, Moul DE, Germain A, Stover A, Dodds NE, Johnston KL, Shablesky-Cade MA, Pilkonis PA. Development and validation of patient-reported outcome measures for sleep disturbance and sleep-related impairments. Sleep, 33(6):781-92, 2010. PMCID: PMC2880437
  9. Buysse DJ, Angst J, Gamma A, Ajdacic V, Eich D, Rossler W. Prevalence, course and comorbidity of insomnia and depression in young adults. Sleep, 31(4):473-80, 2008. PMCID: PMC2279748
  10. Nofzinger EA, Nissen C, Germain A, Moul D, Hall M, Price JC, Miewald JM, Buysse DJ. Regional cerebral metabolic correlates of WASO during sleep in insomnia. Journal of Clinical Sleep Medicine, 2(3):316-22, 2006.
  11. Nofzinger EA, Buysse DJ, Germain A, Price JC, Miewald JM, Kupfer DJ. Functional neuroimaging evidence of hyperarousal in insomnia. American Journal of Psychiatry, 161(11):2126-31, 2004.
  12. Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research. Psychiatry Research, 28(2):193-213, 1989.

Complete list of published work: http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40800059/?sort=date&direction=ascending

 

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