K01 DA032557 (PI: Hasler)
Adolescence is a time of particular vulnerability to substance use disorders; initiation of substance use often occurs during this developmental period, and the progression from first use to substance dependence occurs more rapidly in adolescents than in adults. This project is investigating whether substance-related vulnerabilities may be explained by adolescent changes in circadian rhythms, sleep, and reward function. In a sample of healthy adolescents aged 13-17 years old, we are testing whether experimentally-imposed circadian misalignment alters the neural processing of reward (monetary and social). Findings may have important implications for developing more effective preventive programs to delay substance use initiation and reduce risks for adolescent substance use disorders.