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Michele L. Okun
Assistant Professor of Psychiatry
Ph.D.
Western Psychiatric Institute and Clinic
3811 O'Hara Street; E-1120
Pittsburgh, PA 15213
Phone: (412) 586-9434
Email: okunml@upmc.edu
Fax: (412) 246-5300
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| Education |
BA, University of California Santa Barbara - 1991
MA, San Francisco State University - 1998
PhD, University of Colorado, Denver, and Health Sciences Center - 2005 |
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| Research Interests |
| Michele L. Okun, Ph.D. is Assistant Professor of Psychiatry at the University of Pittsburgh School of Medicine. Dr. Okun received her doctoral degree in Health and Behavioral Sciences at the University of Colorado Denver in 2005. Dr. Okun is interested in evaluating the implications of disturbed sleep on neuroimmune and neuroendocrine markers as they relate to women’s health outcomes. Her present research focuses on the assessment and interpretation of disturbed sleep and inflammation during pregnancy and its role in the incidence of pregnancy complications. |
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| Publications |
Nishino S, Ripley B, Overeem S, Nevsimalova S, Lammers GJ, Vankova J, Okun M, Rogers W, Brooks S, and Mignot E. Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy. Annals of Neurology, 50:381-8, 2001.
Hungs M, Lin L, Okun M, Mignot E. Polymorphisms in the vicinity of the hypocretin/orexin are not associated with human narcolepsy. Neurology. 27:1893-5, 2001.
Mignot E, Lin L, Rogers W, Honda Y, Qiu X, Lin X, Okun M, Hohjoh H, Miki T, Hsu SH, Leffell MS, Grumet F, Fernandez-Vina M, Honda M, Risch N. Complex HLA-DR and -DQ Interactions Confer Risk of Narcolepsy-Cataplexy in Three Ethnic Groups. American Journal of Human Genetics, 68:686-99, 2001.
Okun ML, Lin L, Pelin Z, Hong S, Mignot E. Clinical and genetic aspects of narcolepsy and cataplexy across ethnic groups. Sleep, 25:27-35, 2002.
Mignot E, Lammers GJ, Ripley B, Okun M, Nevsimalova S, Overeem S, Vankova J, Black J, Harsh J, Bassetti C, Schrader H, Nishino S. The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Archives of Neurology, 59:1553-62, 2002.
Hong SC, Leen-Kim, Park SA, Han JH, Lee SP, Lin L, Okun M, Nishino S, Mignot E. HLA and hypocretin studies in Korean patients with narcolepsy. Sleep, 25:440-4, 2002.
Dauvilliers Y, Carlander B, Molinari N, Desautels A, Okun M, Tafti M, Montplaisir J, Mignot E, Billiard M. Month of birth as a risk for narcolepsy. Sleep. 15, 2003.
Shumway M, Sentell T, Chouljian T, Tellier J, Rozewicz F, Okun M. Assessing preferences for schizophrenia outcomes: Comprehension and decision strategies in three assessment methods. Mental Health Services Research, 5:121-35, 2003.
Coussons-Read, M, Okun M, Simms, S. The psychoneuroimmunology of pregnancy. Journal of Reproductive and Infant Psychology, 21:103-12, 2003.
Okun ML, Giese S, Lin L, Einen M, Mignot E, Coussons-Read ME. Exploring the cytokine and endocrine involvement in narcolepsy. Brain, Behavior and Immunity. 18:326-32, 2004.
Coussons-Read ME, Okun ML, Schmitt MP, Giese S. Prenatal stress alters cytokine levels in a manner that may endanger human pregnancy. Psychosomatic Medicine, 67:625-31, 2005.
Ohayon MM and Okun ML. Occurrence of sleep disorders in the families of narcoleptic patients. Neurology. 22;67(4):703-5, 2006.
Okun ML and Coussons-Read ME. Sleep Disruption during Pregnancy: How Does it Influence Serum Cytokines? Journal of Reproductive Immunology, 73:158-65, 2007.
Coussons-Read ME, Okun ML, Nettles C. Psychosocial Stress Increases Inflammatory Markers and Alters Cytokine Production across Pregnancy. Brain, Behavior and Immunity, 21:343-50, 2007.
Okun ML, Hall M, Coussons-Read ME. Sleep Disturbances Increase IL-6 Production during Pregnancy: Implications for Pregnancy Complications. Reproductive Sciences, 14:560-7, 2007.
Okun ML, Kravitz HM, Sowers MF, Moul DE, Buysse DJ, Hall M. Psychometric Evaluation of the Insomnia Symptom Questionnaire: a Self-report Measure to Identify Chronic Insomnia. Journal of Clinical Sleep Medicine, 15:41-51, 2009. PMID:19317380
Okun ML, Coussons-Read ME, Hall M. Disturbed Sleep is Associated with Increased C-reactive protein in Young Women. Brain, Behavior and Immunity, 23: 351-4, 2009. PMID: 19007876
Okun ML, Roberts JM, Marsland AL, Hall M. How disturbed sleep may be a risk factor for adverse pregnancy outcomes. A Hypothesis. Ob-Gyn Survey, 64:273-80, 2009. PMID: 19296861
Okun ML, Hanusa BH, Hall M, Wisner KL. Sleep Complaints in Late Pregnancy and the Recurrence of Postpartum Depression. Behavioral Sleep Medicine, (in press).
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